Name: MNN-02-155
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT219600842
Cas No:3067681-22-2
常用名:MNN-02-155
IUPAC:1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N-[5-(4-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-5-(methylcarbamoyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-1-yl}piperidin-1-yl)-5-oxopentyl]piperidine-4-carboxamide
IUPAC:1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N-[5-(4-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-5-(methylcarbamoyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-1-yl}piperidin-1-yl)-5-oxopentyl]piperidine-4-carboxamide
InChI key:GWSPREFNOSPUJZ-UHFFFAOYSA-N

分子式:C56H68ClF2N15O7
分子量:1136.7
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)C(=O)NCCCCC(=O)N3CCC(CC3)n3nc(N4CCCc5cc(-c6cnn(C)c6)c(cc45)C(F)F)c4CN(CCc34)C(=O)NC)cc(OC)c2n(C)c1=O
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)C(=O)NCCCCC(=O)N3CCC(CC3)n3nc(N4CCCc5cc(-c6cnn(C)c6)c(cc45)C(F)F)c4CN(CCc34)C(=O)NC)cc(OC)c2n(C)c1=O

MNN-02-155 是一种二价分子胶 (molecular glue)，能够同时结合p300/CBP和BCL6。MNN-02-155 还能诱导BCL6靶向报告基因的强效活化，并触发细胞死亡。该化合物适用于弥漫性大B细胞淋巴瘤 (DLBCL) 的研究。

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