Name: TCIP3
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT219600870
Cas No:3067681-36-8
常用名:TCIP3
IUPAC:1-{1-[3-(4-{1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]piperidine-4-carbonyl}piperazin-1-yl)propanoyl]piperidin-4-yl}-3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
IUPAC:1-{1-[3-(4-{1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]piperidine-4-carbonyl}piperazin-1-yl)propanoyl]piperidin-4-yl}-3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
InChI key:NHWQUQINMUWILV-UHFFFAOYSA-N

分子式:C58H71ClF2N16O7
分子量:1177.76
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)C(=O)N3CCN(CCC(=O)N4CCC(CC4)n4nc(N5CCCc6cc(-c7cnn(C)c7)c(cc56)C(F)F)c5CN(CCc45)C(=O)NC)CC3)cc(OC)c2n(C)c1=O
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)C(=O)N3CCN(CCC(=O)N4CCC(CC4)n4nc(N5CCCc6cc(-c7cnn(C)c7)c(cc56)C(F)F)c5CN(CCc45)C(=O)NC)CC3)cc(OC)c2n(C)c1=O

TCIP3 是一种二价分子胶 (molecular glue)，能双重结合p300/CBP和BCL6。通过重定向p300和CBP，TCIP3 激活通常被致癌驱动基因BCL6抑制的程序性细胞死亡基因。TCIP3可用于研究弥漫性大B细胞淋巴瘤 (DLBCL)，且对未转化的扁桃体淋巴细胞或成纤维细胞无毒性。

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