Name: APcK110
Rating: 5 (10 reviews)

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HIT ID:HIT219815496
Cas No:1001083-74-4
常用名:APcK110
IUPAC:6-(3,5-dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine
IUPAC:6-(3,5-dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine
InChI key:InChIKey=CAMGZGMEPKFVMF-UHFFFAOYSA-N

分子式:C20H16FN3O2
分子量:349.365
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(OC)cc(c1)-c1ccc2c(n[nH]c2n1)-c1ccc(F)cc1
SMILES:COc1cc(OC)cc(c1)-c1ccc2c(n[nH]c2n1)-c1ccc(F)cc1

APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling pathways . APcK110 may have potent application in AML.

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