Name: FNIII14
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220772422
Cas No:206536-96-1
常用名:FNIII14
IUPAC:(4S)-4-[(2S)-2-{2-[(2S,3R)-2-[(2S,3S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-4-carboxybutanamido]propanamido]-3-hydroxybutanamido]-3-methylpentanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanamido]-5-[(2S)-2-[({[(1S,2R)-1-{[(1S)-3-carboxy-1-{[(1S)-1-{[(1S,2R)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}methyl)carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid
IUPAC:(4S)-4-[(2S)-2-{2-[(2S,3R)-2-[(2S,3S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-4-carboxybutanamido]propanamido]-3-hydroxybutanamido]-3-methylpentanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanamido]-5-[(2S)-2-[({[(1S,2R)-1-{[(1S)-3-carboxy-1-{[(1S)-1-{[(1S,2R)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}methyl)carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid
InChI key:InChIKey=QDLZSLWZRSJFBC-BSMRXANBSA-N

分子式:C103H163N21O35
分子量:2255.549
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O
SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

FNIII14 来源于纤连蛋白 (FN) 分子的第 14 个 III 型样 (FN-III) 重复序列。它能够抑制细胞与细胞外基质 (ECM) 的粘附，诱导 β1-整合素 (β1integrin) 从活性状态转变为非活性状态，并阻止整合素介导的信号传导。FNIII14 具备抗纤维化和抗癌的特性，可应用于代谢性疾病、器官纤维化及恶性肿瘤的研究。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~