Name: GLP-1R agonist 34
Rating: 5 (10 reviews)

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HIT ID:HIT220773038
Cas No:3074089-99-6
常用名:GLP-1R agonist 34
IUPAC:3-[(1S,2S)-1-{2-[(4S)-3-[3-(1-cyclopropyl-4-fluoro-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyclopropyl]-4,5-dihydro-1,2,4-oxadiazol-5-one
IUPAC:3-[(1S,2S)-1-{2-[(4S)-3-[3-(1-cyclopropyl-4-fluoro-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyclopropyl]-4,5-dihydro-1,2,4-oxadiazol-5-one
InChI key:InChIKey=CROLKJJVEFZMAI-MZXNQBJUSA-N

分子式:C50H50F2N10O5
分子量:909.012
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H]1C[C@]1(c1noc(=O)[nH]1)n1c(cc2cc(ccc12)[C@H]1CCOC(C)(C)C1)C(=O)N1CCc2nn(c(c2[C@@H]1C)-n1ccn(-c2ccc3n(ncc3c2F)C2CC2)c1=O)-c1cc(C)c(F)c(C)c1
SMILES:C[C@H]1C[C@]1(c1noc(=O)[nH]1)n1c(cc2cc(ccc12)[C@H]1CCOC(C)(C)C1)C(=O)N1CCc2nn(c(c2[C@@H]1C)-n1ccn(-c2ccc3n(ncc3c2F)C2CC2)c1=O)-c1cc(C)c(F)c(C)c1

GLP-1R agonist 34 (Compound 1) 是一种口服活性小分子胰高血糖素样肽-1受体 (GLP-1R) 激动剂。其作用包括促进胰岛素分泌、抑制胰高血糖素释放及减缓胃排空，从而有效降低血糖水平。GLP-1R agonist 34 可能用于研究2型糖尿病、肥胖症和非酒精性脂肪性肝炎 (NASH) 等代谢性疾病。

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