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  3. HIT220911949
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HIT220911949
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HIT220911949
  • HIT ID:HIT220911949
  • Cas No:1146944-35-5
  • 常用名:KRC-108
  • IUPAC:3-(1,3-benzoxazol-2-yl)-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
    IUPAC:3-(1,3-benzoxazol-2-yl)-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
  • InChI key:InChIKey=NLOGXCAMKYLWJP-UHFFFAOYSA-N
  • 分子式:C20H20N6O
  • 分子量:360.421
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
    SMILES:Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
  • KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. (source: Invest New Drugs. 2012 Apr;30(2):518-23. doi: 10.1007/s10637-010-9584-2. Epub 2010 Nov 16. ).
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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