Name: E70K TFA
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220911984
Cas No:
常用名:E70K TFA
IUPAC:(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-2-carbamoyl-1-{[(1S)-1-carbamoyl-2-hydroxyethyl]carbamoyl}ethyl]carbamoyl}pentyl]carbamoyl}ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}pentyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}pentyl]carbamoyl}-3-carboxypropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-4-[(2S)-6-amino-2-acetamidohexanamido]butanoic acid; trifluoroacetic acid
IUPAC:(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-2-carbamoyl-1-{[(1S)-1-carbamoyl-2-hydroxyethyl]carbamoyl}ethyl]carbamoyl}pentyl]carbamoyl}ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}pentyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}pentyl]carbamoyl}-3-carboxypropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-4-[(2S)-6-amino-2-acetamidohexanamido]butanoic acid; trifluoroacetic acid
InChI key:InChIKey=FUGRRZPKIYKQRT-LSZCLUPISA-N

分子式:C110H179F3N34O30
分子量:2514.845
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O
SMILES:OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O

E70K是一种抑制趋化因子(C-X-C)配体8 (CXCL8)与细胞膜外的糖胺聚糖(GAGs)之间相互作用的抑制剂。它对应于CXCL8 C末端GAG结合区的氨基酸序列，并在第70位上含有谷氨酸到赖氨酸的替换。在50 nM浓度下，E70K能够抑制初级人类中性粒细胞与人类脐静脉内皮细胞(HUVECs)的结合。当使用浓度范围为1至1,000 nM时，它能降低CXCL8诱导的初级人类中性粒细胞通过HMEC-1人类微血管内皮细胞层的跨内皮迁移。

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
纯度
-
¥ 540.00
1

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