Name: Tertiapin LQ TFA
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220912003
Cas No:
常用名:Tertiapin LQ TFA
别名:TPNLQ
IUPAC:(2S)-6-amino-N-[(1S)-5-amino-1-carbamoylpentyl]-2-(2-{[(1R,4S,7S,10S,16S,19S,22S,25S,28S,31R,36R,39S,42S,45S,52R,55S)-39,42-bis(4-aminobutyl)-52-[(2S)-2-[(2S)-2-aminopropanamido]-4-methylpentanamido]-16,19,22-tris[(2S)-butan-2-yl]-25-(3-carbamimidamidopropyl)-4-(2-carbamoylethyl)-28,55-bis(carbamoylmethyl)-45-[(1H-indol-3-yl)methyl]-7-(2-methylpropyl)-3,6,9,15,18,21,24,27,30,38,41,44,47,53,56-pentadecaoxo-33,34,49,50-tetrathia-2,5,8,14,17,20,23,26,29,37,40,43,46,54,57-pentadecaazatricyclo[29.16.10.0^{10,14}]heptapentacontan-36-yl]formamido}acetamido)hexanamide; trifluoroacetic acid
IUPAC:(2S)-6-amino-N-[(1S)-5-amino-1-carbamoylpentyl]-2-(2-{[(1R,4S,7S,10S,16S,19S,22S,25S,28S,31R,36R,39S,42S,45S,52R,55S)-39,42-bis(4-aminobutyl)-52-[(2S)-2-[(2S)-2-aminopropanamido]-4-methylpentanamido]-16,19,22-tris[(2S)-butan-2-yl]-25-(3-carbamimidamidopropyl)-4-(2-carbamoylethyl)-28,55-bis(carbamoylmethyl)-45-[(1H-indol-3-yl)methyl]-7-(2-methylpropyl)-3,6,9,15,18,21,24,27,30,38,41,44,47,53,56-pentadecaoxo-33,34,49,50-tetrathia-2,5,8,14,17,20,23,26,29,37,40,43,46,54,57-pentadecaazatricyclo[29.16.10.0^{10,14}]heptapentacontan-36-yl]formamido}acetamido)hexanamide; trifluoroacetic acid
InChI key:InChIKey=ZPLMSISGLVMRNO-UKFVICMHSA-N

分子式:C108H180F3N33O26S4
分子量:2542.07
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.[H][C@]1(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)CC
SMILES:OC(=O)C(F)(F)F.[H][C@]1(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)CC

Tertiapin LQ是源自蜜蜂毒素肽tertiapin的肽衍生物，同时也是向内整流钾(Kir)通道的抑制剂。它能够抑制由G蛋白激活的向内整流钾通道1（GIRK1）和GIRK4（即Kir3.1和Kir3.4）组成的异源多聚钾通道，以及向内整流钾通道1（Kir1.1）。在活体内，tertiapin LQ抑制在雪貂中对条件刺激的Purkinje细胞暂停响应。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~