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  3. HIT220912016
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HIT220912016
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HIT220912016
  • HIT ID:HIT220912016
  • Cas No:805242-85-7
  • 常用名:GPI-15427
  • IUPAC:4-[(4-methylpiperazin-1-yl)methyl]-8-oxa-15,16-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,9(17),10,12-heptaen-14-one
    IUPAC:4-[(4-methylpiperazin-1-yl)methyl]-8-oxa-15,16-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,9(17),10,12-heptaen-14-one
  • InChI key:InChIKey=DZRLVSOGARUEGQ-UHFFFAOYSA-N
  • 分子式:C20H20N4O2
  • 分子量:348.406
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CN1CCN(Cc2ccc3oc4cccc5c4c(n[nH]c5=O)c3c2)CC1
    SMILES:CN1CCN(Cc2ccc3oc4cccc5c4c(n[nH]c5=O)c3c2)CC1
  • GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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