Edicotinib HCl | CAS 1559069-92-9 | AnyMole

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HIT220912084

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HIT220912084

HIT ID:HIT220912084
Cas No:1559069-92-9
常用名:Edicotinib HCl
IUPAC:5-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide hydrochloride
IUPAC:5-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide hydrochloride
InChI key:InChIKey=GDFIUUZLRLJTSJ-UHFFFAOYSA-N

分子式:C27H36ClN5O2
分子量:498.07
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
SMILES:Cl.CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1

Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells.

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供应商
TargetMolSC
规格
货期
1-2周
纯度
-
¥ 10,600.00
1

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