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- HIT ID:HIT220912120
- Cas No:73326-98-4
- 常用名:Ellipticine quinone
- InChI key:InChIKey=KPOPOVJXCUAKLY-UHFFFAOYSA-N
- 分子式:C15H8N2O2
- 分子量:248.241
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.). Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.
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- 供应商TargetMol规格货期6-8周纯度-¥ 10,600.001
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