Name: APX2009
Rating: 5 (10 reviews)

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HIT ID:HIT220912157
Cas No:1415030-15-7
常用名:APX2009
IUPAC:N,N-diethyl-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]pentanamide
IUPAC:N,N-diethyl-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]pentanamide
InChI key:InChIKey=WEMXCNYTFZUFSB-UHFFFAOYSA-N

分子式:C21H25NO4
分子量:355.434
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCC(=CC1=C(OC)C(=O)c2ccccc2C1=O)C(=O)N(CC)CC
SMILES:CCCC(=CC1=C(OC)C(=O)c2ccccc2C1=O)C(=O)N(CC)CC

APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.

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