Name: Azelnidipine, (S)-
Rating: 5 (10 reviews)

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HIT ID:HIT220912224
Cas No:722455-09-6
常用名:Azelnidipine, (S)-
IUPAC:3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl (4S)-2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC:3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl (4S)-2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChI key:InChIKey=ZKFQEACEUNWPMT-NDEPHWFRSA-N

分子式:C33H34N4O6
分子量:582.657
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)OC(=O)C1=C(C)NC(N)=C([C@H]1c1cccc(c1)N(=O)=O)C(=O)OC1CN(C1)C(c1ccccc1)c1ccccc1
SMILES:CC(C)OC(=O)C1=C(C)NC(N)=C([C@H]1c1cccc(c1)N(=O)=O)C(=O)OC1CN(C1)C(c1ccccc1)c1ccccc1

Azelnidipine, (S)-, is an L-type calcium channel blocker (CCB). Studies have shown that in patients with hypertension (HT) and heart failure preserved ejection fraction (HFpEF), azelnidipine improved the severity of HF and cardiac sympathetic nerve activity compared with cilnidipine, an N-type CCB (Cat#326734).

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