Name: IRBP (651-670) (human) TFA
Rating: 5 (10 reviews)

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HIT ID:HIT220912323
Cas No:
常用名:IRBP (651-670) (human) TFA
别名:IRBP651-670, Interphotoreceptor Retinoid-Binding Protein (651-670)
别名:IRBP651-670, Interphotoreceptor Retinoid-Binding Protein (651-670)
IUPAC:(4S)-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-4-methylpentanamido]propanamido]-4-carbamoylbutanamido]acetamido}propanamido]-3-(4-hydroxyphenyl)propanamido]-5-carbamimidamidopentanamido]-3-hydroxybutanamido]propanamido]-3-methylbutanamido]-3-carboxypropanamido]-4-methylpentanamido]-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(1S)-1-{[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl}-3-methylbutyl]carbamoyl}propyl]carbamoyl}-2-hydroxyethyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}butanoic acid; trifluoroacetic acid
IUPAC:(4S)-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-4-methylpentanamido]propanamido]-4-carbamoylbutanamido]acetamido}propanamido]-3-(4-hydroxyphenyl)propanamido]-5-carbamimidamidopentanamido]-3-hydroxybutanamido]propanamido]-3-methylbutanamido]-3-carboxypropanamido]-4-methylpentanamido]-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(1S)-1-{[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl}-3-methylbutyl]carbamoyl}propyl]carbamoyl}-2-hydroxyethyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}butanoic acid; trifluoroacetic acid
InChI key:InChIKey=SXKFLEPZATZNNY-NDTDTKSPSA-N

分子式:C93H152F3N25O34
分子量:2221.375
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.[H][C@](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(C)C)([C@@H](C)O)C(O)=O
SMILES:OC(=O)C(F)(F)F.[H][C@](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(C)C)([C@@H](C)O)C(O)=O

IRBP651-670（Interphotoreceptor retinoid-binding protein (651-670)）是IRBP（亦称为retinoid-binding protein 3）的肽段，参与色素再生，通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中，利用IRBP651-670诱导自身免疫性葡萄膜炎，这些小鼠携带H-2b单体型。用IRBP651-670（300 µg/动物）免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平，免疫细胞浸润及光感受器损伤。

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
5日内发货
纯度
-
¥ 650.00
1

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