Name: KI-328
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT220912763
Cas No:930089-25-1
常用名:KI-328
IUPAC:methyl N-[4-(2-{[5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(phenylamino)pyrimidin-2-yl]amino}ethyl)phenyl]carbamate
IUPAC:methyl N-[4-(2-{[5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(phenylamino)pyrimidin-2-yl]amino}ethyl)phenyl]carbamate
InChI key:InChIKey=DRWABHOVZJWFLU-UHFFFAOYSA-N

分子式:C25H25N7O3
分子量:471.521
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)Nc1ccc(CCNc2ncc(-c3nnc(o3)C3CC3)c(Nc3ccccc3)n2)cc1
SMILES:COC(=O)Nc1ccc(CCNc2ncc(-c3nnc(o3)C3CC3)c(Nc3ccccc3)n2)cc1

KI-328 is a novel KIT inhibitor. KI-328 shows selective potency against KIT kinase for the in vitro kinase assay, and inhibits the growth of wild-type (Wt)- and mutant-KIT-expressing cells, while it has little potency against D816V-KIT.

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