Name: Chlorhexidine-d8 HCl
Rating: 5 (10 reviews)

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HIT ID:HIT220912765
Cas No:2012598-75-1
常用名:Chlorhexidine-d8 HCl
IUPAC:N-[4-chloro(2,3,5,6-2H4)phenyl]-1-(N'-{6-[N-({N'-[4-chloro(2,3,5,6-2H4)phenyl]carbamimidamido}methanimidoyl)amino]hexyl}carbamimidamido)methanimidamide dihydrochloride
IUPAC:N-[4-chloro(2,3,5,6-2H4)phenyl]-1-(N'-{6-[N-({N'-[4-chloro(2,3,5,6-2H4)phenyl]carbamimidamido}methanimidoyl)amino]hexyl}carbamimidamido)methanimidamide dihydrochloride
InChI key:InChIKey=WJLVQTJZDCGNJN-ZYNYSASXSA-N

分子式:C22H32Cl4N10
分子量:586.42
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.[2H]c1c([2H])c(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2c([2H])c([2H])c(Cl)c([2H])c2[2H])c([2H])c([2H])c1Cl
SMILES:Cl.Cl.[2H]c1c([2H])c(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2c([2H])c([2H])c(Cl)c([2H])c2[2H])c([2H])c([2H])c1Cl

Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively). Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml). It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay. Formulations containing chlorhexidine have been used in antisept......

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