Name: PHA-680626
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT220912770
Cas No:398493-74-8
常用名:PHA-680626
IUPAC:4-(4-methylpiperazin-1-yl)-N-{5-[2-(thiophen-2-yl)acetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide
IUPAC:4-(4-methylpiperazin-1-yl)-N-{5-[2-(thiophen-2-yl)acetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide
InChI key:InChIKey=BMCKWRUTJXVUFF-UHFFFAOYSA-N

分子式:C23H26N6O2S
分子量:450.56
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2CN(Cc12)C(=O)Cc1cccs1
SMILES:CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2CN(Cc12)C(=O)Cc1cccs1

PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM).

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