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  3. HIT220912786
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HIT220912786
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HIT220912786
  • HIT ID:HIT220912786
  • Cas No:919767-02-5
  • 常用名:KRN383
  • IUPAC:{4-[(7-hydroxy-6-methoxyquinolin-4-yl)oxy]cyclohexa-1,5-dien-1-yl}urea
    IUPAC:{4-[(7-hydroxy-6-methoxyquinolin-4-yl)oxy]cyclohexa-1,5-dien-1-yl}urea
  • InChI key:InChIKey=FDEJMZJEHJWMRY-UHFFFAOYSA-N
  • 分子式:C17H17N3O4
  • 分子量:327.34
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1cc2c(OC3CC=C(NC(N)=O)C=C3)ccnc2cc1O
    SMILES:COc1cc2c(OC3CC=C(NC(N)=O)C=C3)ccnc2cc1O
  • KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies.
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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