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  3. HIT220912805
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HIT220912805
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HIT220912805
  • HIT ID:HIT220912805
  • Cas No:1627843-95-1
  • 常用名:PH11
  • IUPAC:methyl 2-({4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a][1,3,5]triazin-2-yl}amino)benzoate
    IUPAC:methyl 2-({4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a][1,3,5]triazin-2-yl}amino)benzoate
  • InChI key:InChIKey=HOGIPROMEUJZIJ-UHFFFAOYSA-N
  • 分子式:C22H22N6O5
  • 分子量:450.455
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)n2ccnc2n1
    SMILES:COC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)n2ccnc2n1
  • PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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