Name: Amsacrine gluconate
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT220912843
Cas No:80277-07-2
常用名:Amsacrine gluconate
IUPAC:(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; N-{4-[(acridin-9-yl)amino]-3-methoxyphenyl}methanesulfonamide
IUPAC:(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; N-{4-[(acridin-9-yl)amino]-3-methoxyphenyl}methanesulfonamide
InChI key:InChIKey=XXNAQBNJPZNRSZ-IFWQJVLJSA-N

分子式:C27H31N3O10S
分子量:589.62
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
SMILES:OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12

Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.

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