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HIT220912868
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HIT220912868
  • HIT ID:HIT220912868
  • Cas No:1370023-80-5
  • 常用名:Deleobuvir sodium
  • IUPAC:sodium (2E)-3-(2-{1-[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-amido]cyclobutyl}-1-methyl-1H-1,3-benzodiazol-6-yl)prop-2-enoate
    IUPAC:sodium (2E)-3-(2-{1-[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-amido]cyclobutyl}-1-methyl-1H-1,3-benzodiazol-6-yl)prop-2-enoate
  • InChI key:InChIKey=YJADTGFGJMFOLM-KJEVSKRMSA-M
  • 分子式:C34H32BrN6NaO3
  • 分子量:675.563
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[Na+].Cn1c(c(C2CCCC2)c2ccc(cc12)C(=O)NC1(CCC1)c1nc2ccc(\C=C\C([O-])=O)cc2n1C)-c1ncc(Br)cn1
    SMILES:[Na+].Cn1c(c(C2CCCC2)c2ccc(cc12)C(=O)NC1(CCC1)c1nc2ccc(\C=C\C([O-])=O)cc2n1C)-c1ncc(Br)cn1
  • Deleobuvir sodium is the salt form of Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell below 50%, however, for dual regimens without ribavirin and for genotype 1a patients. In December 2013, deleobuvir was discontinued since recent findings from phase III trials did not suggest sufficient efficacy.
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  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 15,000.00
    1

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