Name: MK-8666 Tris
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT220912924
Cas No:2056254-98-7
常用名:MK-8666 Tris
IUPAC:(2S,3S,4R)-8-{[4'-(3-methanesulfonylpropoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl]methoxy}-9-azatricyclo[4.4.0.0^{2,4}]deca-1(10),6,8-triene-3-carboxylic acid; 2-amino-2-(hydroxymethyl)propane-1,3-diol
IUPAC:(2S,3S,4R)-8-{[4'-(3-methanesulfonylpropoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl]methoxy}-9-azatricyclo[4.4.0.0^{2,4}]deca-1(10),6,8-triene-3-carboxylic acid; 2-amino-2-(hydroxymethyl)propane-1,3-diol
InChI key:InChIKey=IMBNJMBRVNORTO-SQMFDTLJSA-N

分子式:C33H42N2O9S
分子量:642.76
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:NC(CO)(CO)CO.[H][C@@]12Cc3cc(OCc4cccc(c4)-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)ncc3[C@]1([H])[C@H]2C(O)=O
SMILES:NC(CO)(CO)CO.[H][C@@]12Cc3cc(OCc4cccc(c4)-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)ncc3[C@]1([H])[C@H]2C(O)=O

MK-8666 Tris is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 Tris has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.

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