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  3. HIT220912935
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HIT220912935
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HIT220912935
  • HIT ID:HIT220912935
  • Cas No:136451-58-6
  • 常用名:BMY-42393
  • IUPAC:2-{3-[2-(4,5-diphenyl-1,3-oxazol-2-yl)ethyl]phenoxy}acetic acid
    IUPAC:2-{3-[2-(4,5-diphenyl-1,3-oxazol-2-yl)ethyl]phenoxy}acetic acid
  • InChI key:InChIKey=AZZHJQQOAHWBPN-UHFFFAOYSA-N
  • 分子式:C25H21NO4
  • 分子量:399.446
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:OC(=O)COc1cccc(CCc2nc(c(o2)-c2ccccc2)-c2ccccc2)c1
    SMILES:OC(=O)COc1cccc(CCc2nc(c(o2)-c2ccccc2)-c2ccccc2)c1
  • BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. BMY 42393 competed for radiolabeled iloprost and PGE1 binding to platelet membranes (IC50; 170 nM and 130 nM, respectively).
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 13,900.00
    1

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