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- HIT ID:HIT220912936
- Cas No:16722-44-4
- 常用名:JJO-1
- InChI key:InChIKey=FOOVLXYORBIGKA-UHFFFAOYSA-N
- 分子式:C19H13N3
- 分子量:283.334
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the γ subunit adenylate-nucleotide binding sites or deletion of the β subunit carbohydrate-binding module.
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- 供应商TargetMol规格货期6-8周纯度-¥ 10,600.001
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