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  3. HIT220912942
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HIT220912942
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HIT220912942
  • HIT ID:HIT220912942
  • Cas No:688036-19-3
  • 常用名:SU-11752
  • IUPAC:3-(2,4-diethyl-5-{[2-oxo-5-(phenylsulfamoyl)-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
    IUPAC:3-(2,4-diethyl-5-{[2-oxo-5-(phenylsulfamoyl)-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
  • InChI key:InChIKey=QUYIGDGKOSEELL-UHFFFAOYSA-N
  • 分子式:C26H27N3O5S
  • 分子量:493.58
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCc1[nH]c(C=C2C(=O)Nc3ccc(cc23)S(=O)(=O)Nc2ccccc2)c(CC)c1CCC(O)=O
    SMILES:CCc1[nH]c(C=C2C(=O)Nc3ccc(cc23)S(=O)(=O)Nc2ccccc2)c(CC)c1CCC(O)=O
  • SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 12,800.00
    1

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