Name: Phenylbutazone-d9
Rating: 5 (10 reviews)

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HIT ID:HIT220912944
Cas No:1189479-75-1
常用名:Phenylbutazone-d9
IUPAC:4-[(1,1,2,2,3,3,4,4,4-2H9)butyl]-1,2-diphenylpyrazolidine-3,5-dione
IUPAC:4-[(1,1,2,2,3,3,4,4,4-2H9)butyl]-1,2-diphenylpyrazolidine-3,5-dione
InChI key:InChIKey=VYMDGNCVAMGZFE-ABVHXWLASA-N

分子式:C19H20N2O2
分子量:317.436
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
SMILES:[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1

Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis. Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

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