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  3. HIT220912956
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HIT220912956
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HIT220912956
  • HIT ID:HIT220912956
  • Cas No:80860-82-8
  • 常用名:Brivudine monophosphate
  • IUPAC:{[(2R,3S,5R)-5-{5-[(1E)-2-bromoethenyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
    IUPAC:{[(2R,3S,5R)-5-{5-[(1E)-2-bromoethenyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
  • InChI key:InChIKey=LKWCVKAHHUJPQO-PIXDULNESA-N
  • 分子式:C11H14BrN2O8P
  • 分子量:413.117
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(\C=C\Br)c(=O)[nH]c1=O
    SMILES:O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(\C=C\Br)c(=O)[nH]c1=O
  • Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 13,900.00
    1

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