Name: RWJ-58643 HCl
Rating: 5 (10 reviews)

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HIT ID:HIT220913009
Cas No:287182-52-9
常用名:RWJ-58643 HCl
IUPAC:(2S,4R)-1-acetyl-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide hydrochloride
IUPAC:(2S,4R)-1-acetyl-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide hydrochloride
InChI key:InChIKey=RJGFYDAIAYFTCT-BGYHIHCLSA-N

分子式:C20H27ClN6O4S
分子量:482.98
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.CC(=O)N1C[C@H](O)C[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)c1nc2ccccc2s1
SMILES:Cl.CC(=O)N1C[C@H](O)C[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)c1nc2ccccc2s1

RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo.

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