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  3. HIT220913046
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HIT220913046
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HIT220913046
  • HIT ID:HIT220913046
  • Cas No:1236361-78-6
  • 常用名:Pimasertib HCl
  • IUPAC:N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide hydrochloride
    IUPAC:N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide hydrochloride
  • InChI key:InChIKey=HIEXZUXKTABHCP-PPHPATTJSA-N
  • 分子式:C15H16ClFIN3O3
  • 分子量:467.66
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F
    SMILES:Cl.OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F
  • Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    1-2周
    纯度
    -
    ¥ 10,600.00
    1

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