Name: MEDS433
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT220913068
Cas No:2241027-61-0
常用名:MEDS433
IUPAC:2-oxo-N-{2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl}-1H,2H-pyrazolo[1,5-a]pyridine-3-carboxamide
IUPAC:2-oxo-N-{2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl}-1H,2H-pyrazolo[1,5-a]pyridine-3-carboxamide
InChI key:InChIKey=JIIXZPWFDKPNKW-UHFFFAOYSA-N

分子式:C20H11F4N3O2
分子量:401.321
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Fc1c(F)c(c(F)c(F)c1NC(=O)c1c2ccccn2[nH]c1=O)-c1ccccc1
SMILES:Fc1c(F)c(c(F)c(F)c1NC(=O)c1c2ccccn2[nH]c1=O)-c1ccccc1

MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.

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