Name: GBR-12935 maleate
Rating: 5 (10 reviews)

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HIT ID:HIT220913082
Cas No:1349767-56-1
常用名:GBR-12935 maleate
IUPAC:(2Z)-but-2-enedioic acid; 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
IUPAC:(2Z)-but-2-enedioic acid; 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
InChI key:InChIKey=QCSMGOCTDJAWRQ-BTJKTKAUSA-N

分子式:C32H38N2O5
分子量:530.665
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)\C=C/C(O)=O.C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1
SMILES:OC(=O)\C=C/C(O)=O.C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1

GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (Â¹Â²Â³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. (Source: http://en.wikipedia.org/wiki/GBR-12935).

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