AZD-6918 | CAS 905585-60-6 | AnyMole

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HIT220913085

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HIT220913085

HIT ID:HIT220913085
Cas No:905585-60-6
常用名:AZD-6918
IUPAC:5-fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-{[5-(propan-2-yloxy)-1H-pyrazol-3-yl]amino}pyridine-3-carbonitrile
IUPAC:5-fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-{[5-(propan-2-yloxy)-1H-pyrazol-3-yl]amino}pyridine-3-carbonitrile
InChI key:InChIKey=QRAQXWWNHQMCBH-LBPRGKRZSA-N

分子式:C20H20F2N6O
分子量:398.418
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(cc2F)C#N)n[nH]1
SMILES:CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(cc2F)C#N)n[nH]1

AZD6918 is a novel potent and selective inhibitor of the Trk tyrosine kinases. AZD-6918 attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. AZD6918 inhibited wild-type TrkB-induced cell migration and cell growth.

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TargetMolSC
规格
货期
6-8周
纯度
-
¥ 10,600.00
1

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