Name: ASP3662
Rating: 5 (10 reviews)

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HIT ID:HIT220913099
Cas No:1204178-50-6
常用名:ASP3662
IUPAC:4-{5-[2-(4-chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide
IUPAC:4-{5-[2-(4-chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide
InChI key:InChIKey=CMQOKZCYVZFZLZ-UHFFFAOYSA-N

分子式:C19H16ClF3N4O2
分子量:424.81
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1c(nnc1C(C)(C)Oc1c(F)cc(Cl)cc1F)-c1ccc(cc1F)C(N)=O
SMILES:Cn1c(nnc1C(C)(C)Oc1c(F)cc(Cl)cc1F)-c1ccc(cc1F)C(N)=O

ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia. ASP3662 inhibited human, mouse and rat 11β-HSD1 but not human 11β-HSD2, in vitro. ASP3662 inhibited in vitro conversion of glucocorticoid from its inactive to active form in extracts of rat brain and spinal cord.

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