Name: BMS-186511
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220913114
Cas No:
常用名:BMS-186511
IUPAC:(2-{[(1S)-1-{[(1S)-1-{[(2S)-1-methoxy-4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl)[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phosphinic acid
IUPAC:(2-{[(1S)-1-{[(1S)-1-{[(2S)-1-methoxy-4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl)[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phosphinic acid
InChI key:InChIKey=QNNCDQUXVSUVDG-QKFLMABSSA-N

分子式:C34H60N3O7PS
分子量:685.9
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCP(O)(=O)C\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(C)C)C(C)C
SMILES:COC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCP(O)(=O)C\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(C)C)C(C)C

BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~