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  3. HIT220913118
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HIT220913118
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HIT220913118
  • HIT ID:HIT220913118
  • Cas No:
  • 常用名:F-1394
  • IUPAC:(1S,2S)-2-{[(2,2-dimethylpropyl)(nonyl)carbamoyl]amino}cyclohexyl 3-{[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]formamido}propanoate
    IUPAC:(1S,2S)-2-{[(2,2-dimethylpropyl)(nonyl)carbamoyl]amino}cyclohexyl 3-{[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]formamido}propanoate
  • InChI key:InChIKey=NWLFOBZKYXKBOF-NSVAZKTRSA-N
  • 分子式:C33H61N3O6
  • 分子量:595.866
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCCCCCN(CC(C)(C)C)C(=O)N[C@H]1CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H]1OC(C)(C)OCC1(C)C
    SMILES:CCCCCCCCCN(CC(C)(C)C)C(=O)N[C@H]1CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H]1OC(C)(C)OCC1(C)C
  • F-1394 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall. F-1394 significantly reduced neointimal thickening and the extent of macrophages in lesions without affecting serum cholesterol levels. In vitro, F-1394 attenuated foam cell formation in mouse peritoneal macrophages.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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