Name: LCRF-0004
Rating: 5 (10 reviews)

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HIT ID:HIT220913137
Cas No:
常用名:LCRF-0004
IUPAC:N-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
IUPAC:N-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
InChI key:InChIKey=DVRMYRDLCLUXQP-UHFFFAOYSA-N

分子式:C28H18F4N6O2S
分子量:578.55
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
SMILES:Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1

LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.

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