Name: Totrombopag choline
Rating: 5 (10 reviews)

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HIT ID:HIT220913235
Cas No:851606-62-7
常用名:Totrombopag choline
IUPAC:(2-hydroxyethyl)trimethylazanium; 5-(3'-{2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]diazen-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-yl)-1H-1,2,3,4-tetrazol-1-ide
IUPAC:(2-hydroxyethyl)trimethylazanium; 5-(3'-{2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]diazen-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-yl)-1H-1,2,3,4-tetrazol-1-ide
InChI key:InChIKey=JKVHRBKMPPIUNC-UHFFFAOYSA-N

分子式:C30H35N9O3
分子量:569.67
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[N+](C)(C)CCO.CC1=NN(C(=O)C1N=Nc1cccc(-c2cccc(c2)-c2nnn[n-]2)c1O)c1ccc(C)c(C)c1
SMILES:C[N+](C)(C)CCO.CC1=NN(C(=O)C1N=Nc1cccc(-c2cccc(c2)-c2nnn[n-]2)c1O)c1ccc(C)c(C)c1

Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and potent agonist of the TPO receptor and therefore induces differentiation and proliferation of megakaryocytes. The pharmacologic characteristics indicate potential therapeutic use in thrombocytopenic patients with a variety of clinical etiologies.

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