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HIT220913371
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HIT220913371
  • HIT ID:HIT220913371
  • Cas No:1232841-78-9
  • 常用名:PBT434 HBr
  • IUPAC:5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one hydrobromide
    IUPAC:5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one hydrobromide
  • InChI key:InChIKey=WNTSHYWJAPIRQE-UHFFFAOYSA-N
  • 分子式:C12H14BrCl2N3O2
  • 分子量:383.07
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Br.CCNCc1nc2c(O)c(Cl)cc(Cl)c2c(=O)n1C
    SMILES:Br.CCNCc1nc2c(O)c(Cl)cc(Cl)c2c(=O)n1C
  • PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 12,800.00
    1

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