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HIT220913393
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HIT220913393
  • HIT ID:HIT220913393
  • Cas No:866883-79-6
  • 常用名:FI-700
  • IUPAC:5-{5-[(piperazin-1-yl)methyl]-1,3,4-oxadiazol-2-yl}-N4-propyl-N2-[2-(pyridin-4-yl)ethyl]pyrimidine-2,4-diamine
    IUPAC:5-{5-[(piperazin-1-yl)methyl]-1,3,4-oxadiazol-2-yl}-N4-propyl-N2-[2-(pyridin-4-yl)ethyl]pyrimidine-2,4-diamine
  • InChI key:InChIKey=AOGSXPPPFJBSRA-UHFFFAOYSA-N
  • 分子式:C21H29N9O
  • 分子量:423.525
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCNc1nc(NCCc2ccncc2)ncc1-c1nnc(CN2CCNCC2)o1
    SMILES:CCCNc1nc(NCCc2ccncc2)ncc1-c1nnc(CN2CCNCC2)o1
  • FI-700 is a novel and potent FLT3 inhibitor with promising antileukemia activity. FI-700 showed a potent IC(50) value against FLT3 kinase at 20 nmol/L in an in vitro kinase assay. FI-700 showed selective growth inhibition against mutant FLT3-expressing leukemia cell lines and primary acute myeloid leukemia cells, whereas it did not affect the FLT3 ligand (FL)-driven growth of Wt-FLT3-expressing cells. Oral administration of FI-700 induced the regression of tumors in a s.c. tumor xenograft model and increased the survival of mice in an i.v. transplanted model. Furthermore, FI-700 treatment eradicated FLT3/ITD-expressing leukemia cells, both in the peripheral blood and in the bone marrow. (Source: Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4575-82.)
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 13,900.00
    1

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