Name: Tylogenin
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT220913448
Cas No:135247-46-0
常用名:Tylogenin
IUPAC:(1R,2R,4aS,4bR,8R,8aS,9S,10aR)-1,8-bis(acetyloxy)-2-[(2R)-2-methoxy-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2,4b-dimethyl-7-oxo-tetradecahydrophenanthren-9-yl acetate
IUPAC:(1R,2R,4aS,4bR,8R,8aS,9S,10aR)-1,8-bis(acetyloxy)-2-[(2R)-2-methoxy-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2,4b-dimethyl-7-oxo-tetradecahydrophenanthren-9-yl acetate
InChI key:InChIKey=RTKXYQUBRFXSOY-NHKUMSDUSA-N

分子式:C28H38O10
分子量:534.602
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12C[C@H](OC(C)=O)[C@@]3([H])[C@@H](OC(C)=O)C(=O)CC[C@]3(C)[C@@]1([H])CC[C@@](C)([C@@H]2OC(C)=O)C1=CC(=O)O[C@@]1(C)OC
SMILES:[H][C@@]12C[C@H](OC(C)=O)[C@@]3([H])[C@@H](OC(C)=O)C(=O)CC[C@]3(C)[C@@]1([H])CC[C@@](C)([C@@H]2OC(C)=O)C1=CC(=O)O[C@@]1(C)OC

Tylogenin, a steroidal aglycone generated by acid hydrolysis from two seasonal glycosides occurring in Tylophora sylvatica, inhibits IgE-induced basophil mediator release for allergic reactions. In the rabbit basophil-dependent serotonin release (BDSR) assay system, the inhibitory activity of tylogenin was significantly greater than that of its parent glycosides, tylophoroside and acetyltylophoroside, and that of dexamethasone. The activity of tylogenin was found to increase with the incubation time. In the human leukocyte-dependent histamine release test model, the glycosides had only a minimal activity. In contrast, tylogenin, with a geom mean IC50 = 49 microM, exerted a significantly greater potency than dexamethasone. These results suggest that tylogenin could represent a new class of antiallergic agents.

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