Name: CAM741
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT220913453
Cas No:177586-74-2
常用名:CAM741
IUPAC:propyl 3-[(2R,5S,8S,11S,14S,17S,20S)-14-[(1-methoxy-1H-indol-3-yl)methyl]-7,13,19,20-tetramethyl-5,17-bis[(2R)-2-methylhexyl]-8,11-bis(2-methylpropyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosan-2-yl]propanoate
IUPAC:propyl 3-[(2R,5S,8S,11S,14S,17S,20S)-14-[(1-methoxy-1H-indol-3-yl)methyl]-7,13,19,20-tetramethyl-5,17-bis[(2R)-2-methylhexyl]-8,11-bis(2-methylpropyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosan-2-yl]propanoate
InChI key:InChIKey=VDFZHYIUDDBVPN-IVUNSTSTSA-N

分子式:C56H91N7O11
分子量:1038.382
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCC[C@@H](C)C[C@@H]1NC(=O)[C@@H](CCC(=O)OCCC)OC(=O)[C@H](C)N(C)C(=O)[C@H](C[C@H](C)CCCC)NC(=O)[C@H](Cc2cn(OC)c3ccccc23)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C1=O
SMILES:CCCC[C@@H](C)C[C@@H]1NC(=O)[C@@H](CCC(=O)OCCC)OC(=O)[C@H](C)N(C)C(=O)[C@H](C[C@H](C)CCCC)NC(=O)[C@H](Cc2cn(OC)c3ccccc23)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C1=O

CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.

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