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HIT220913462
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HIT220913462
  • HIT ID:HIT220913462
  • Cas No:906481-23-0
  • 常用名:STA-9584
  • IUPAC:(2S)-2-amino-N-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-1,2-oxazol-4-yl]phenyl}-3-phenylpropanamide hydrochloride
    IUPAC:(2S)-2-amino-N-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-1,2-oxazol-4-yl]phenyl}-3-phenylpropanamide hydrochloride
  • InChI key:InChIKey=DPEXZURXDJIYRS-BOXHHOBZSA-N
  • 分子式:C28H30ClN3O6
  • 分子量:540.01
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.COc1ccc(cc1NC(=O)[C@@H](N)Cc1ccccc1)-c1cnoc1-c1cc(OC)c(OC)c(OC)c1
    SMILES:Cl.COc1ccc(cc1NC(=O)[C@@H](N)Cc1ccccc1)-c1cnoc1-c1cc(OC)c(OC)c(OC)c1
  • STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584 ) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P).
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  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 12,800.00
    1

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