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  3. HIT220913465
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HIT220913465
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HIT220913465
  • HIT ID:HIT220913465
  • Cas No:2043026-13-5
  • 常用名:Roxadustat-d5
  • IUPAC:2-({4-hydroxy-1-methyl-7-[(2,3,4,5,6-2H5)phenoxy]isoquinolin-3-yl}formamido)acetic acid
    IUPAC:2-({4-hydroxy-1-methyl-7-[(2,3,4,5,6-2H5)phenoxy]isoquinolin-3-yl}formamido)acetic acid
  • InChI key:InChIKey=YOZBGTLTNGAVFU-VIQYUKPQSA-N
  • 分子式:C19H16N2O5
  • 分子量:357.377
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[2H]c1c([2H])c([2H])c(Oc2ccc3c(O)c(nc(C)c3c2)C(=O)NCC(O)=O)c([2H])c1[2H]
    SMILES:[2H]c1c([2H])c([2H])c(Oc2ccc3c(O)c(nc(C)c3c2)C(=O)NCC(O)=O)c([2H])c1[2H]
  • Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and HIF-2α in Hep3B hepatocellular carcinoma cells. It increases levels of secreted erythropoietin in Hep3B cells in a concentration-dependent manner and increases erythropoiesis in rats when administered at doses of 25 and 50 mg/kg. Roxadustat reverses anemia in a rat model of chronic inflammation induced by peptidoglycan-polysaccharide, as well as a rat model of chronic kidney disease induced by 5/6 nephrectomy. It reduces tumor growth and increases survival in a murine Lewis lung carcin......
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 11,500.00
    1

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