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  3. HIT220913475
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HIT220913475
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HIT220913475
  • HIT ID:HIT220913475
  • Cas No:1189558-88-0
  • 常用名:CDKI-83
  • IUPAC:4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[4-methyl-3-(morpholine-4-sulfonyl)phenyl]amino}pyrimidine-5-carbonitrile
    IUPAC:4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[4-methyl-3-(morpholine-4-sulfonyl)phenyl]amino}pyrimidine-5-carbonitrile
  • InChI key:InChIKey=SSEDQERECATUBR-UHFFFAOYSA-N
  • 分子式:C21H23N7O3S2
  • 分子量:485.58
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CNc1nc(C)c(s1)-c1nc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)ncc1C#N
    SMILES:CNc1nc(C)c(s1)-c1nc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)ncc1C#N
  • CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 12,800.00
    1

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