LY2780301 | CAS 1226801-23-5 | AnyMole

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HIT220913490

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HIT220913490

HIT ID:HIT220913490
Cas No:1226801-23-5
常用名:LY2780301
IUPAC:4-(4-{1-[2-(dimethylamino)ethyl]-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}piperidin-1-yl)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
IUPAC:4-(4-{1-[2-(dimethylamino)ethyl]-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}piperidin-1-yl)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one
InChI key:InChIKey=YDFKZIGAUIKZGP-UHFFFAOYSA-N

分子式:C25H27F4N7O
分子量:517.533
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc2NC(=O)Cc12)-c1ccc(F)c(c1)C(F)(F)F
SMILES:CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc2NC(=O)Cc12)-c1ccc(F)c(c1)C(F)(F)F

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

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供应商
TargetMolSC
规格
货期
8-10周
纯度
-
¥ 13,900.00
1

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