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  3. HIT220913578
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HIT220913578
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HIT220913578
  • HIT ID:HIT220913578
  • Cas No:
  • 常用名:AM-9635
  • IUPAC:4-amino-6-{[(1S)-1-[6-fluoro-1-(5-fluoropyridin-3-yl)-1H-1,3-benzodiazol-2-yl]ethyl]amino}pyrimidine-5-carbonitrile
    IUPAC:4-amino-6-{[(1S)-1-[6-fluoro-1-(5-fluoropyridin-3-yl)-1H-1,3-benzodiazol-2-yl]ethyl]amino}pyrimidine-5-carbonitrile
  • InChI key:InChIKey=QLWGSXWLXIBFPF-JTQLQIEISA-N
  • 分子式:C19H14F2N8
  • 分子量:392.374
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cncc(F)c1
    SMILES:C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cncc(F)c1
  • AM-9635 is a potent and selective PI3Kδ inhibitor. AM-9635 showes good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-96352 inhibits KLH-specific IgG and IgM in a dosedependent manner AM-9635 is well tolerated at all doses and exhibits significantly reduced IgG and IgM specific antibodies . PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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