Name: BIIB028
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220913629
Cas No:911398-13-5
常用名:BIIB028
IUPAC:[(4-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}but-3-yn-1-yl)oxy]phosphonic acid
IUPAC:[(4-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}but-3-yn-1-yl)oxy]phosphonic acid
InChI key:InChIKey=BMZGPNGECPQAGB-UHFFFAOYSA-N

分子式:C19H21ClN5O5P
分子量:465.83
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1c(C)cnc(Cn2cc(C#CCCOP(O)(O)=O)c3c(Cl)nc(N)nc23)c1C
SMILES:COc1c(C)cnc(Cn2cc(C#CCCOP(O)(O)=O)c3c(Cl)nc(N)nc23)c1C

BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~