Name: CH5164840
Rating: 5 (10 reviews)

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HIT ID:HIT220913654
Cas No:1052645-73-4
常用名:CH5164840
IUPAC:4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1^{2,6}]docosa-1(20),2(22),3,5,17(21),18-hexaene-10,16-dione
IUPAC:4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1^{2,6}]docosa-1(20),2(22),3,5,17(21),18-hexaene-10,16-dione
InChI key:InChIKey=OMFBVBRFVYLRQT-UHFFFAOYSA-N

分子式:C19H23N5O2S
分子量:385.49
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(C)c2cc1-c1cc(SCCC(=O)NCCCNC2=O)nc(N)n1
SMILES:Cc1cc(C)c2cc1-c1cc(SCCC(=O)NCCCNC2=O)nc(N)n1

CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations.

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