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  3. HIT220913672
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HIT220913672
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HIT220913672
  • HIT ID:HIT220913672
  • Cas No:622856-21-7
  • 常用名:PD-321852
  • IUPAC:4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]-1H,2H,3H,6H-pyrrolo[3,4-c]carbazole-1,3-dione
    IUPAC:4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]-1H,2H,3H,6H-pyrrolo[3,4-c]carbazole-1,3-dione
  • InChI key:InChIKey=WEIYKGMSZPBORY-UHFFFAOYSA-N
  • 分子式:C24H19Cl2N3O3
  • 分子量:468.33
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CNCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl
    SMILES:CNCCCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1c(Cl)cccc1Cl
  • PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.
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  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 11,700.00
    1

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