Name: OP-145 TFA
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT220913727
Cas No:
常用名:OP-145 TFA
别名:P60.4-Ac, acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide
别名:P60.4-Ac, acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide
IUPAC:(4S)-4-{[(1S)-1-{[(1R,2S)-1-{[(1S)-5-amino-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-3-carboxypropyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}butyl]carbamoyl}pentyl]carbamoyl}-2-methylbutyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-4-[(2S)-2-[(2R,3S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-{2-[(2R,3S)-2-acetamido-3-methylpentanamido]acetamido}hexanamido]-4-carboxybutanamido]-3-phenylpropanamido]hexanamido]-5-carbamimidamidopentanamido]-3-methylpentanamido]-3-methylbutanamido]butanoic acid; trifluoroacetic acid
IUPAC:(4S)-4-{[(1S)-1-{[(1R,2S)-1-{[(1S)-5-amino-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-3-carboxypropyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}butyl]carbamoyl}pentyl]carbamoyl}-2-methylbutyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-4-[(2S)-2-[(2R,3S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-{2-[(2R,3S)-2-acetamido-3-methylpentanamido]acetamido}hexanamido]-4-carboxybutanamido]-3-phenylpropanamido]hexanamido]-5-carbamimidamidopentanamido]-3-methylpentanamido]-3-methylbutanamido]butanoic acid; trifluoroacetic acid
InChI key:InChIKey=KAAYBUZUNSPRGS-FCQSJDAQSA-N

分子式:C144H247F3N46O33
分子量:3207.844
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.[H][C@](NC(C)=O)([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
SMILES:OC(=O)C(F)(F)F.[H][C@](NC(C)=O)([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

OP-145是一种合成抗菌肽及抗菌肽LL-37的衍生物。它对E. coli、P. aeruginosa、C. albicans和A. niger具有活性（MICs分别为2、3、6和18 µM）。含有OP-145的聚乳酸-共-聚乙二醇酸（PLGA）微球能够在骨折部位接种细菌后通过外科股骨骨折所诱导的小鼠骨感染模型中防止生物膜的形成。

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
纯度
-
¥ 750.00
1

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